Brands, Tim (2022) The Key Components of Successful Cognitive Remediation for Schizophrenia: A Systematic Review and Network Meta-Analysis. Master thesis, Psychology.
|
Text
PDFMaster_Thesis_S2938855_Tim_Brands_Final_Draft.pdf Download (2MB) | Preview |
Abstract
Cognitive remediation (CR) is an evidence-based treatment targeting cognitive deficits in people with schizophrenia. CR aims at improving real-world functioning. A recent expert consensus established (1) cognitive exercises, (2) administration through a trained therapist, (3) strategy training, and (4) procedures to generalize cognitive improvements as core components for CR treatments to be effective in achieving this goal. This study examined the available literature to determine which combination of these components is associated with the greatest improvements in functional outcomes. The databases PubMed, Cochrane Library, and PsycInfo were searched for randomised control trials that included participants diagnosed with schizophrenia, implemented cognitive exercises, and included a functional outcome measure. A Bayesian random effect network meta-analysis (NMA) was conducted to compare the different combinations of CR components with each other. Study quality was appraised using the Risk of Bias tool 2.0. The NMA included 51 studies (4183 participants) and revealed that combining all four components was the configuration that was associated with the greatest improvement in functional outcome at post-treatment and had the highest likelihood (90.88%) of being the most effective component configuration. Meta-regressions identified administrator training and psychiatric rehabilitation as two moderators of the influence of CR on functional outcome at post-treatment. Our results (1) accentuate the importance of integrating all four components for CR to be effective, (2) the importance to differentiate between isolated cognitive exercises and CR and (3) point at the importance of strategy training while questioning the centrality of cognitive exercises in CR.
| Item Type: | Thesis (Master) |
|---|---|
| Supervisor name: | Poppe, A. |
| Degree programme: | Psychology |
| Differentiation route: | Clinical Neuropsychology (CN) [Master Psychology] |
| Date Deposited: | 31 Jan 2022 10:38 |
| Last Modified: | 11 Feb 2022 15:13 |
| URI: | http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/103 |
Actions (login required)
 |
View Item |