Galiën, Jelle van der (2024) The Association between Endocrine Functioning and the Manifestation of Psychotic, Mood and Anxiety Symptoms: A Scoping Review. Master thesis, Psychology.
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Abstract
INTRODUCTION: This review explored and summarized current research on how endocrine functioning influence the manifestation of psychotic, mood, and anxiety (PMA) symptoms, considering their roles in physiological processes and impacting brain functions. It delves into the bidirectional relationship between endocrine functioning and PMA symptoms, emphasizing the need for further understanding in both clinical and research contexts. METHODS: This scoping review systematically synthesized the current literature on the association between endocrine functioning, hormone imbalances and the manifestation of PMA symptoms. Literature search for the last ten years on PsycINFO and MEDLINE and subsequent screening led to 51 included studies. Data were extracted and analyzed to identify trends, gaps, and potential mechanisms linking endocrine functioning to PMA symptomology. The review adhered to PRISMA-ScR guidelines for comprehensive reporting. RESULTS: Key hormone types found to be associated with PMA symptoms include sex hormones, stress hormones, thyroid hormones, appetite hormones, and oxytocin. Key findings underscore sex-specific effects of sex hormones related to the sexually dimorphic PMA symptom presentation. A dysregulated HPA axis, including high cortisol levels, shows significant associations with psychotic symptoms and increased susceptibility for mood and anxiety symptom development, particularly following early-life stress. Thyroid hormone imbalances can mimic and exacerbate neuropsychiatric symptoms, and appetite and metabolic hormones showed associations with psychotic and anxiety symptoms via metabolic dysregulation and neuroinflammatory pathways. Lastly, oxytocin modulates stress and social cognition, with low levels impacting PMA symptoms. CONCLUSION: This study revealed the complex interplay between endocrine functioning and PMA symptoms. Findings were often heterogeneous and associations limited. Hormone-symptom relationships are not solely causal but interact with genetic, biological, and environmental factors, influencing brain function and predisposing individuals to PMA symptoms. Future transdiagnostic and multidisciplinary research strategies could enhance diagnostic and treatment approaches related to these manifestations.
| Item Type: | Thesis (Master) |
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| Supervisor name: | Larabi, D.I. |
| Degree programme: | Psychology |
| Differentiation route: | Clinical Neuropsychology (CN) [Master Psychology] |
| Date Deposited: | 26 Jul 2024 06:47 |
| Last Modified: | 26 Jul 2024 06:47 |
| URI: | http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/4159 |
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