Bosch, Charlotte (2024) The Relationship Between Gray Matter Volume, Set-Shifting and Depressive Symptoms in Mild Cognitive Impairment. Master thesis, Psychology.
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Abstract
Gray matter atrophy in the medial and lateral prefrontal cortex have been linked to depression and furthermore to executive dysfunction in mild cognitive impairment (MCI). In our study we tested for difference in gray matter (GM) volume in the frontal cortex in individuals with and without set-shifting dysfunction and whether depressive symptoms influenced this relationship. A total of fifty-six individuals were divided into the amnestic MCI group with (N = 12) and without (N = 44) set-shifting dysfunction. After preprocessing of the magnetic resonance imaging (MRI) data and segmentation of tissue type, T1 weighted anatomical images were analyzed with statistical nonparametric mapping. There was no significant difference in gray matter volume between the groups. Only in the aMCI group, at an uncorrected threshold, we found atrophy related to depressive symptoms in several regions of the frontal cortex. We were not able to find support for our hypothesis that there is an interactive relationship between set-shifting dysfunction, depressive symptoms and GM volume in patient with amnestic MCI. Possible explanations for this discrepancy are discussed, as are future directions for research.
| Item Type: | Thesis (Master) |
|---|---|
| Supervisor name: | Aleman, A. |
| Degree programme: | Psychology |
| Differentiation route: | Clinical Neuropsychology (CN) [Master Psychology] |
| Date Deposited: | 13 Aug 2024 12:48 |
| Last Modified: | 13 Aug 2024 12:48 |
| URI: | http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/4259 |
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