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The Contribution of the Cerebellum on Working Memory Volume with Patients with a Mild Cognitive Impairment

Ferdinandus, Lucas (2024) The Contribution of the Cerebellum on Working Memory Volume with Patients with a Mild Cognitive Impairment. Master thesis, Psychology.

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Abstract

The present study aims to investigate the relationship between cerebellar volume and cognitive performance in patients with Mild Cognitive Impairment (MCI), using data from the Dutch COGMAX study. Working memory (WM) performance was assessed using the average hit rate and d-prime of average performance from the n-back (2-back) task. T1-weighted structural magnetic resonance imaging data of thirty-one patients (male: M = 73.1, SD, = 5.1; female: M = 73.4, SD, = 14.1) were analysed to assess volumes of cerebellar subregions. Voxel-based morphometry with the SUIT toolbox was used to measure brain structure at the voxel level. A general linear model analysis was used to examine the relationships between cerebellar volumes and cognitive performance, controlling for education and age. The analysis revealed a significant association between lobule 7 and WM performance on the 2-back task. No significant association was found between lobule 8 and WM performance. Additionally, higher education levels were associated with better WM performance, and an interaction effect was identified between education level and cerebellar volume, suggesting that the influence of cerebellar volume varies depending on education level.

Item Type: Thesis (Master)
Supervisor name: Aleman, A.
Degree programme: Psychology
Differentiation route: Clinical Neuropsychology (CN) [Master Psychology]
Date Deposited: 25 Sep 2024 14:05
Last Modified: 25 Sep 2024 14:05
URI: http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/4392

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