Torres Coll, Jaume (2025) Effects of Epilepsy and Anti-Epileptic Medication on Cognitive Functioning in Glioma Patients: A Systematic Literature Review. Research Master thesis, Research Master.
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Abstract
Abstract Background: Thorough evidence on the effects of epilepsy and anti-epileptic medication on cognitive functioning in glioma patients is currently deficient. This systematic literature review evaluates the impact of epilepsy and antiepileptic drugs (AEDs) on cognitive domains by identifying consistent findings and discrepancies in the literature, and offering insights to guide future research and the clinical care. Methods: A systematic search of PubMed’s electronic database was conducted to identify all relevant articles published up to October 2024. Data extraction was carried out using a standardized form based on the Cochrane Handbook for Systematic Reviews of Interventions and given the variability in cognitive outcomes and the heterogeneity of the studies, a narrative synthesis guided by Popay et al., (2006) was employed as the primary method of analysis. Results: A total of 27 studies published between 2003 and 2024 were included, involving 3,774 participants, of whom 2,920 were glioma patients. These studies explored various aspects of cognitive functioning, with a particular focus on the impact of epilepsy and anti- epileptic drugs (AEDs) on cognitive outcomes. Key areas of investigation included seizure frequency and type, assessment of cognitive domains, and the effects of different AEDs. Conclusion: Cognitive impairment is a significant concern in glioma patients, with both epilepsy and anti-epileptic medication contributing to cognitive challenges. Regular neuropsychological evaluations can help diagnose specific cognitive impairments in this population and monitor their progression, and newer AEDs may aid in mitigating some of the common cognitive impairments.
| Item Type: | Thesis (Research Master) |
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| Supervisor name: | Buunk, A.M. and Heutink, J.H.C. |
| Degree programme: | Research Master |
| Differentiation route: | Mental health: perspectives from Neuro- and Clinical Psychology [Research Master] |
| Date Deposited: | 02 Apr 2025 09:42 |
| Last Modified: | 02 Apr 2025 09:42 |
| URI: | http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/4807 |
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