Rheenen, Adam van (2022) Glutamaat-glutamine in rusttoestand in het frontopariëtale netwerk en werkgeheugenprestatie voor patiënten met een milde cognitieve stoornis. Master thesis, Psychology.
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Abstract
Introduction Up to 50% of patients with amnestic Mild Cognitive Impairment (aMCI) develop full Alzheimer dementia within 30 months. An increasing amount of research suggests that poor working memory (WM) performance predicts progression from aMCI to AD. The WM process has been attributed to the frontoparietal brain network. We measured glutamate-glutamine (Glx) concentrations in two regions of the frontoparietal network and investigated associations with WM performance and memory performance. Methods We used the data of 11 patients with MCI. They had participated in the Cogmax-study, a double-blind, randomized trial comparing the effect of synchronous transcranial alternating current stimulation (tACS) and sham stimulation on brain synchronization and cognitive performance. Glx concentration (measured with ¹H functional magnetic resonance spectrometry, ¹H-fMRS), WM performance (measured with WAIS – digit span test) and memory performance (measured with RAVLT) were evaluated at study baseline and after 10 days of stimulation. The outcome measure of interest was the change in Glx concentration between these timepoints and was analysed with a repeated measures ANOVA, as well as the association between Glx concentration and WM performance and between Glx concentration and memory performance. Additionally, we inspected whether having a memory impairment, based on RAVLT scores, was associated with lower Glx concentrations at baseline. Results and conclusion Our findings show that Glx concentrations in the left dorsolateral prefrontal cortex (DLPFC), but not in the left parietal lobe (PL), are associated with memory impairment. We found that WM performance and memory performance differed numerically but not significantly across baseline and post-stimulation measurements. We found that changes in WM performance and memory performance, across baseline and post-stimulation measurements, were not associated with a change in Glx concentration. This indicated that, using the current small sample size (n = 11), no within patient associations could be found between Glx concentrations and WM/memory performance, but between patient association between baseline Glx concentrations and memory impairment were found.
| Item Type: | Thesis (Master) |
|---|---|
| Supervisor name: | Aleman, A. and Curcic-Blake, B. |
| Degree programme: | Psychology |
| Differentiation route: | Clinical Neuropsychology (CN) [Master Psychology] |
| Date Deposited: | 23 Jun 2022 10:09 |
| Last Modified: | 23 Jun 2022 10:09 |
| URI: | http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/589 |
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