Subgroups of Solid Organ Transplant Recipients with Moderate to Severe Fatigue

Doberstein, Demian (2025) Subgroups of Solid Organ Transplant Recipients with Moderate to Severe Fatigue. Bachelor thesis, Psychology.

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Abstract

Fatigue is a prevalent and debilitating symptom in solid organ transplant recipients (SOTR), yet it remains poorly understood. This exploratory study aimed to identify clinically meaningful subgroups within a fatigued SOTR population to inform future targeted interventions. Cross-sectional data collected one-year post-transplant were drawn from the TransplantLines Biobank and Cohort Study (n = 360; multiple organ types). Participants with moderate to severe fatigue were selected, and latent profile analysis was conducted using key psychosocial indicators: depressive symptoms, perceived control, physical quality of life and negative social support. Three profiles emerged: a Low Burden group and two higher burden groups, labeled: Personal Burden and Social Burden. The Low Burden profile while displaying moderated severe scores did show very positive scores across the related variables. Burdened profiles differed on depressive symptoms and social support with the Social Burden Profile showing elevated scores in both. Sociodemographic differences were found with the Low Burden group including more men, higher employment rates, and more individuals in relationships, while the Social Burden group showed the highest rates of disability leave and lowest partnership rates. No significant clinical differences were observed. The identified profiles support a more differentiated clinical approach tailored to specific SOTR care needs. Future research should attempt to refine subgroups and study the suggested clinical implications, to develop targeted efficient interventions

Item Type:	Thesis (Bachelor)
Supervisor name:	Pijnenborg, G.H.M.
Degree programme:	Psychology
Differentiation route:	None [Bachelor Psychology]
Date Deposited:	27 Aug 2025 08:30
Last Modified:	27 Aug 2025 08:30
URI:	http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/5891

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