Publication Biases in the Reporting of Efficacy Outcomes of Randomized Controlled Trials of Fluoxetine, Escitalopram, and Escitalopram for the Treatment of Major Depressive Disorder in the Pediatric Population

Klingenberg, Arina (2022) Publication Biases in the Reporting of Efficacy Outcomes of Randomized Controlled Trials of Fluoxetine, Escitalopram, and Escitalopram for the Treatment of Major Depressive Disorder in the Pediatric Population. Bachelor thesis, Psychology.

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Abstract

The current research investigates Publication Bias in Randomized controlled trials (RCTs) of Escitalopram, Citalopram, and Fluoxetine for the treatment of Major Depressive Disorder (MDD) in the pediatric population. A systematic literature search was conducted to match trials registered with the FDA to its publication. For that, we searched PubMed, PsycINFO, Google Scholar, ClinicalTrials.gov. I was able to match all eight trials with its publications. In addition, I looked for Selective Publication Bias, Selective Outcome Reporting Bias, Spin Bias, and Pooled Publication Bias. Two out of eight trials were considered positive by the FDA. Two out of six negative trials displayed a publication bias in the form of either Spin or Outcome Reporting Bias. Over and above, the remaining four negative trials did not show any form of bias according to our definition. Nevertheless, other issues, including design flaws and lack of robustness in the findings, questioned the outcomes’ credibility. Lastly, possible reasons for the occurrence of biases are discussed, and possible solutions to decrease its availability are suggested.

Item Type:	Thesis (Bachelor)
Supervisor name:	Roest, A.M. and Vries, Y.A. de
Degree programme:	Psychology
Differentiation route:	None [Bachelor Psychology]
Date Deposited:	04 Jul 2022 08:06
Last Modified:	04 Jul 2022 08:06
URI:	http://gmwpublic.studenttheses.ub.rug.nl/id/eprint/610

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